To be played on 9th/10th April or 16th/17th April 2022

10th April 2022 0 - 9 EDF Challenge Cup - Quarter Finals N/A Birmingham DFC v St John’s DFC
17th April 2022 2 - 3 EDF Challenge Cup - Quarter Finals N/A Carlisle City DFC v Welling United DFC
24th April 2022 6 - 1 EDF Challenge Cup - Quarter Finals N/A Farsley Celtic DFC v St Albans City DFC
24th April 2022 1 - 2 EDF Challenge Cup - Quarter Finals N/A Bristol City DFC v Barnet DFC